An often overlooked physiological relationship that dictates adaptations to exercise is the connective link between the nervous system, immune system, and the endocrine system -- collectively called neuroendocrine-immunology. In response to exercise the tissues must undergo metabolic and cellular processes to support the demands of the work being performed. The harder the work, the more the tissue is “disrupted” from its homeostatic state. Contractile forces upset and damage the muscle fiber, metabolism alters tissue and blood chemistry, and the demand for oxygen challenges the cardiopulmonary system. These acute alterations serve to support and satisfy the effort. One of the contributing su
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