A common inquiry among exercise enthusiasts is the specific physiological cause of muscular fatigue. Scientists at Columbia declare that they have not only come up with a response, but have also devised an experimental drug that has been tested in mice that can actually prolong exercise time to exhaustion. The physiological cause of muscular fatigue has been largely ignored and misunderstood for decades. Muscular fatigue due to lactic acid release was a popular theory early on , but exercise physiologists realized it is simply a plausible component based on intensity and physical condition and has since been discredited as the main cause of muscular fatigue according to Dr. George Brooks, from the University of California, Berkeley. In a recent report published in an early online edition of Proceedings of the National Academy of Sciences, Dr. Andrew Marks, the principal investigator of the new study, claims that calcium flow inside the muscle cells is the most likely cause of fatigue.
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